Biotinylated Human CD40 Ligand/TNFSF5 Trimer Protein (Primary Amine Labeling)

Recombinant Biotinylated Human CD40 Ligand/TNFSF5 Trimer Protein (Primary Amine Labeling) is expressed from HEK293 with His tag and Flag tag at the N-Terminus.It contains Met113-Leu261. CD40 ligand or CD40L, also called CD154,  is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, alpha5beta1 integrin and alphaIIbbeta3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells.