beta-NGF (mouse, recombinant)

beta-Nerve growth factor (beta-NGF) is a neurotrophin that is involved in the regulation of growth, proliferation, and survival of sympathetic and sensory neurons. Ngf encodes pro-NGF, a 27 kDa protein that is composed of an N-terminal signal peptide and alpha-, gamma-, and beta-NGF domains. beta-NGF, also known as mature or functional NGF, is produced after degradation of the signaling peptide and proteolytic cleavage. beta-NGF homodimerizes and induces neurotropic signaling through tropomyosin-related kinase A (TrkA) and the p75 neurotrophin receptor (p75NTR). beta-NGF is produced by neurons in the cortex, pituitary gland, hippocampus, basal ganglia, thalamus, spinal cord, and retina, as well as in non-neuronal target cells of sympathetic and sensory neurons such as keratinocytes, vascular smooth muscle cells, exocrine salivary glands, and endocrine tissues. Exogenous administration of beta-NGF improves neurological deficits in murine models of traumatic brain injury (TBI). Exogenous administration of beta-NGF also accelerates the rate of skin excision wound healing in rats. Cayman's beta-NGF (mouse, recombinant) protein can be used for cell-based assay applications. This protein consists of 121 amino acids and has a calculated molecular weight of 13.5 kDa.Synonyms: beta-Nerve Growth Factor, NGFbeta. Purity: >96% estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg, determined by the LAL endotoxin assay. Source: Active recombinant mouse beta-NGF expressed in CHO cells. Amino Acids: 122-241. MW: 13.5 kDa. Formulation: (Request formulation change), Lyophilized from sterile 20 mM NaAc, 150 mM sodium chloride, pH 5.5. UniProt Accession #: P01139.