Recombinant Cytokines

Recombinant IL-4Ra (interleukin-4 receptor subunit alpha), transcript variant 1, also known as CD124, encompassing amino acids 26-232 of the extracellular domain. This construct contains the Fc domain of human IgG1 fused to the C-terminus, followed by a C-terminal Avi-Tag(TM). The recombinant protein was affinity...

Recombinant IL-4Ra (interleukin-4 receptor subunit alpha), transcript variant 1, also known as CD124, encompassing amino acids 26-232. This construct contains the Fc domain of human IgG1 fused to the C-terminus, followed by a C-terminal Avi-Tag(TM). The recombinant protein was enzymatically biotinylated using the...

Recombinant IL-4 (interleukin 4), transcript variant 1, encompassing amino acids 25-153(end). This construct contains a C-terminal Avi-Tag(TM) followed by a His-tag (6xHis). The recombinant protein was affinity purified.

Recombinant IL-4 (interleukin 4), transcript variant 1, encompassing amino acids 25-153(end). This construct contains a C-terminal Avi-Tag(TM) followed by a His-tag (6xHis). The recombinant protein was enzymatically biotinylated using the Avi-Tag(TM) and affinity purified.

Protein function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal...

Protein function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM...

Protein function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Promotes brown adipocyte differentiation by P38 MAPK pathway-mediated activation of target genes, including...

Protein function: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273,...

Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical...

Tag: C-Human Fc tag. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further...

Tag: C-6×His tag. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular...

Tag: C-Human Fc tag. This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. [provided by RefSeq, Jul 2008] Protein function: May be...