Recombinant Cytokines

Recombinant human IL-31 (interleukin 31), encompassing amino acids 24-164(end). This construct contains an N-terminal His-tag (6xHis) followed by an Avi-Tag(TM). This protein is enzymatically biotinylated using Avi-Tag(TM) technology and affinity purified.

NK Cell Culture Cytokine Cocktail 2 is an optimized 1000x cytokine mixture designed to support primary NK cell culture, using BPS Bioscience mbIL15 Based Growth Arrested NK Feeder Cells (#82374) in combination with NK Medium, Serum-Free (#82615).

Protein function: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. [The UniProt Consortium]

Protein function: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching...

Protein function: [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in...

Protein function: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. {ECO:0000269, PubMed:10023777, ECO:0000269, PubMed:10655506, ECO:0000269, PubMed:31213488}. [The UniProt Consortium]

Protein function: Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12909640, PubMed:23661675, PubMed:25495645). Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. Has a...

Protein function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin....

Protein function: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. [The UniProt Consortium]

Protein function: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045,...

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors, fms-like...

VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in...