Recombinant Cytokines

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is...

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Promotes brown adipocyte...

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2...

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity...

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (PubMed:8824192, PubMed:7891723). Both activities result in the...

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds...

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: Chemotactic factor that attracts monocytes. This protein can bind heparin. [The UniProt Consortium]

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell...

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils. [The UniProt Consortium]

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors...

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. [The UniProt Consortium]

Endotoxin level: < 10 EU/mg of the protein as determined by the LAL method. Protein function: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:23255360, PubMed:18025225, PubMed:19144317). IL17A- IL17F signals via IL17RA-IL17RC...