Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Primary pulmonary hypertension (PPH) is a condition of unknown cause that is characterized by... more
Product information "Treprostinil"
Primary pulmonary hypertension (PPH) is a condition of unknown cause that is characterized by increasing pulmonary arterial and vascular resistance. Treprostinil is a stable analog of prostacyclin (Cay-18220) that is used clinically for the treatment of PPH under the trade name Remodulin(TM). The structural modifications in treprostinil compared to prostacyclin increase the plasma half-life from 2 minutes to 34 and 85 minutes for intravenous and subcutaneous infusion of the drug, respectively. In addition to treprostinil's direct vasodilatory effects, it also inhibits inflammatory cytokine (TNFalpha, IL-1beta, IL-6, GM-CF) production by human alveolar macrophages in the sub-micromolar range by preventing NF-kappaB translocation to the nucleus.Formal Name: 2-[[(1R,2R,3aS,9aS)-2,3,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-acetic acid. CAS Number: 81846-19-7. Synonyms: BW 15AU, LRX 15, Rumodolin, U-62840, Uniprost. Molecular Formula: C23H34O5. Formula Weight: 390.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20mg/ml, Ethanol: 20mg/ml. lambdamax: 206, 218, 277 nm. SMILES: O=C(O)COC1=C(C[C@](C[C@@H](O)[C@@H]2CC[C@@H](O)CCCCC)([H])[C@]2([H])C3)C3=CC=C1. InChi Code: InChI=1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1. InChi Key: PAJMKGZZBBTTOY-ZFORQUDYSA-N.
Keywords: | BW 15AU, LRX 15, Rumodolin, U-62840, Uniprost, 2-[[(1R,2R,3aS,9aS)-2,3,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-acetic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10162 |
Properties
Application: | Prostacyclin analog, prostaglandin I2 receptor agonist |
MW: | 390.5 D |
Formula: | C23H34O5 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 81846-19-7| Matching products |
KEGG ID : | K04263 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
![]() ![]() |
H Phrases: | H301, H311, H315, H319, H331, H335, H361, H372 |
P Phrases: | P201, P202, P260, P261, P264, P270, P271, P280, P311, P312, P314, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P332+P313, P337+P313, P361+P364, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed