Description: Treprostinil (Orenitram) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM). Target: Prostaglandin Receptor. Smiles: CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@@H]2Cc3c(C[C@H]12)cccc3OCC(O)=O. References: Whittle BJ, et al. Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and...

Primary pulmonary hypertension (PPH) is a condition of unknown cause that is characterized by increasing pulmonary arterial and vascular resistance. Treprostinil is a stable analog of prostacyclin (Cay-18220) that is used clinically for the treatment of PPH under the trade name Remodulin(TM). The structural...