TOFA

TOFA
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10005263-5 5 mg -

3 - 10 business days*

37.00€
Cay10005263-10 10 mg -

3 - 10 business days*

69.00€
Cay10005263-50 50 mg -

3 - 10 business days*

290.00€
Cay10005263-100 100 mg -

3 - 10 business days*

508.00€
 
Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to... more
Product information "TOFA"
Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines. TOFA is an inhibitor of fatty acid synthesis blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC). Both cerulenin (at about 10 µg/ml) and TOFA (at about 1 µg/ml) are effective at blocking the incorporation of radiolabeled acetate into palmitate. However, TOFA reduces malonyl-CoA levels rather than elevating them, and TOFA is relatively non-toxic to various cancer cell lines. TOFA also attenuates the inhibition of feeding observed when FASN inhibitors such as cerulenin and C75 are administered to obese ob/ob mice. Formal Name: 5-(tetradecyloxy)-2-furancarboxylic acid. CAS Number: 54857-86-2. Synonyms: RMI 14514, 5-(Tetradecyloxy)-2-furoic Acid. Molecular Formula: C19H32O4. Formula Weight: 324.5. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:1): .5 mg/ml, DMSO: 2 mg/ml, Ethanol: 1 mg/ml. lambdamax: 278 nm. SMILES: CCCCCCCCCCCCCCOc1ccc(o1)C(=O)O. InChi Code: InChI=1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21). InChi Key: CZRCFAOMWRAFIC-UHFFFAOYSA-N.
Keywords: 5-(Tetradecyloxy)-2-furoic Acid, RMI 14514, 5-(tetradecyloxy)-2-furancarboxylic acid
Supplier: Cayman Chemical
Supplier-Nr: 10005263

Properties

Application: Bioactive lipid assays
MW: 324.5 D
Formula: C19H32O4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 54857-86-2| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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