Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines. TOFA is an inhibitor of fatty acid synthesis blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC). Both cerulenin (at about 10 µg/ml) and TOFA (at about 1...

Description: TOFA (MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-alpha (ACCA). Target: Acetyl-CoA Carboxylase. Smiles: O(CCCCCCCCCC CCCC)C=1OC(C(O)=O)=CC1. References: Wang C, et al. Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis. Biochem Biophys Res Commun. 2009 Jul...

Fatty acid synthase (FASN) inhibitor. Cell permeable, potent, reversible and competitive inhibitor of acetyl-CoA carboxylase (ACC) consequently blocking the synthesis of malonyl-CoA. Useful agent for immunometabolism research. Anticancer agent. Induces apoptosis in a variety of tumor cell lines. Relatively...