Saikosaponin B1

Saikosaponin B1 is a triterpenoid saponin that has been found in B. chinense and has diverse biological activities. It is an agonist of the serotonin (5-HT) receptor subtype 5-HT2C (EC50 = 147.41 µM in HEK293 cells expressing the human receptor in a calcium mobilization assay). Saikosaponin B1 (100 µg/ml) stimulates prostaglandin E2 (PGE2, Cay-14010) production in isolated rat peritoneal macrophages. It protects SH-SY5Y cells from hydrogen peroxide-induced cell death when used at a concentration of 50 µg/ml.Formal Name: (3beta,4alpha,16beta)-16,23,28-trihydroxyoleana-11,13(18)-dien-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl-beta-D-galactopyranoside. CAS Number: 58558-08-0. Molecular Formula: C42H68O13. Formula Weight: 781.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 243, 251, 261 nm. SMILES: C[C@]12C(C=C[C@@]3([H])[C@]2(CC[C@]4([H])[C@@]3(CC[C@@H]([C@@]4(C)CO)O[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)C)O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)O)C)C)=C7[C@@]([C@H](C1)O)(CCC(C)(C7)C)CO. InChi Code: InChI=1S/C42H68O13/c1-21-29(47)34(55-35-32(50)31(49)30(48)24(18-43)53-35)33(51)36(52-21)54-28-11-12-38(4)25(39(28,5)19-44)10-13-40(6)26(38)9-8-22-23-16-37(2,3)14-15-42(23,20-45)27(46)17-41(22,40)7/h8-9,21,24-36,43-51H,10-20H2,1-7H3/t21-,24-,25-,26-,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,38+,39+,40-,41-,42-/m1/s1. InChi Key: WRYJYFCCMSVEPQ-MNIDVGFKSA-N. Origin: Plant/Unspecified sp..