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RP 001 is a potent sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 9 pM). It is competitive with W146 (Cay-10009109), a selective S1P1 antagonist, and induces internalization and polyubiquitination of S1P1 in a dose-dependent manner. RP 001 induces dose-dependent lymphopenia in mice (EC50 = 0.03 mg/kg). It reduces S1P1-EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1eGFP/eGFP mice but has no effect in vivo. RP 001 also completely inhibits M. stadtmanae (MSS) rechallenge-induced enlargement of B cell-rich tertiary lymphoid tissues (TLTs) and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis.Formal Name: N-[4-[5-[3-cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-beta-alanine, monohydrochloride. CAS Number: 1781880-34-9. Molecular Formula: C24H24N4O4 . HCl. Formula Weight: 468.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM. SMILES: OC(CCNC1CCC2=C(C3=NOC(C4=CC(C#N)=C(OC(C)C)C=C4)=N3)C=CC=C21)=O.Cl. InChi Code: InChI=1S/C24H24N4O4.ClH/c1-14(2)31-21-9-6-15(12-16(21)13-25)24-27-23(28-32-24)19-5-3-4-18-17(19)7-8-20(18)26-11-10-22(29)30,/h3-6,9,12,14,20,26H,7-8,10-11H2,1-2H3,(H,29,30),1H. InChi Key: ZHPGSGYEFGEZAL-UHFFFAOYSA-N.
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