Prostaglandin Metabolite HPLC Mixture

Prostaglandin Metabolite HPLC Mixture
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10005-1 1 each -

6 - 10 business days*

This mixture contains the primary metabolites of prostaglandins (PGs) D2, E2, and F2alpha.... more
Product information "Prostaglandin Metabolite HPLC Mixture"
This mixture contains the primary metabolites of prostaglandins (PGs) D2, E2, and F2alpha. Contents: 13,14-dihydro-15-keto PGD2, 13,14-dihydro-15-keto PGE2, 11beta-PGF2alpha, 13,14-dihydro-15-keto PGF2alpha, and PGF2beta (100 µg each). In primates, the lung is an active site of PG inactivation via 15-hydroxy PG dehydrogenase (15-hydroxy PGDH). E and F-series PGs are good substrates for 15-hydroxy PGDH, which oxidizes the C-15 hydroxyl group to give the corresponding 15-keto compounds. This oxidation if followed rapidly by Delta13-reductase removal of the 13,14-double bond, to give 13,14-dihydro-15-keto PG metabolites. While the primary PGs are often undetectable in plasma due to their rapid inactivation, the 13,14-dihydro-15-keto metabolites can be present at concentrations of several hundred pg/ml. In addition, 9- and 11-keto PG-reductases have been reported, especially in the case of PGD2, which produce F-series PG metabolites with a beta-hydroxyl group on the ring. These metabolites span a wide polarity range and separate well on reversed phase HPLC. Synonyms: PG Metabolite HPLC Mixture. Purity: >98% for each compound. Formulation: A solution in methyl acetate.
Keywords: PG Metabolite HPLC Mixture
Supplier: Cayman Chemical
Supplier-Nr: 10005


Application: Bioactive lipid assays
Purity: >98% for each compound
Format: Solution

Database Information

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H302, H319, H336, H360
P Phrases: P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+310, P303+361+353, P304+340, P305+351+338, P308+313, P312, P330, P337+313, P370+378, P403+233, P403+235, P405, P501
Our products are for laboratory research use only: Not for administration to humans!
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