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Product information "Prostaglandin I2 (sodium salt)"
Prostaglandin I2 (PGI2) is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells. It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 of 5 nM. PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto PGF1alpha in neutral or acidic solutions. The half-life is short both in vivo and in vitro, ranging from 30 seconds to a few minutes. PGI2 is administered by continuous infusion in humans for the treatment of idiopathic pulmonary hypertension.Formal Name: 6,9alpha-epoxy-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monosodium salt. CAS Number: 61849-14-7. Synonyms: Epoprostenol, PGI2, Prostacyclin. Molecular Formula: C20H31O5 . Na. Formula Weight: 374.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 10 mg/ml*, PBS (pH >10.2): 10 mg/ml, Water: 10 mg/ml. SMILES: CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(O2)=C/CCCC([O-])=O.[Na+]. InChi Code: InChI=1S/C20H32O5.Na/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22,/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24),/q,+1/p-1/b11-10+,15-8-,/t14-,16+,17+,18+,19-,/m0./s1. InChi Key: LMHIPJMTZHDKEW-XQYLJSSYSA-M.
Keywords:
Epoprostenol, PGI2, Prostacyclin, 6,9alpha-epoxy-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monosodium salt
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