Prostaglandin D2 Ethanolamide-d4

Prostaglandin D2 ethanolamide (PGD2-EA)-d4 contains four deuterium atoms. It is intended for use as an internal standard for the quantification of PGD2-EA by GC- or LC-mass spectrometry. PGD2-EA is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide.. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.Formal Name: N-(2-hydroxyethyl)-11-oxo-9alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-amide-d4. Synonyms: PGD2-EA-d4, Prostamide D2-d4. Molecular Formula: C22H33D4NO5. Formula Weight: 399.6. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 8.3 mg/ml, DMSO: 8.3 mg/ml, Ethanol: 12.5 mg/ml, PBS (pH 7.2): 2.5 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(NC([2H])([2H])C([2H])([2H])O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C(C1)=O. InChi Code: InChI=1S/C22H37NO5/c1-2-3-6-9-17(25)12-13-19-18(20(26)16-21(19)27)10-7-4-5-8-11-22(28)23-14-15-24/h4,7,12-13,17-20,24-26H,2-3,5-6,8-11,14-16H2,1H3,(H,23,28)/b7-4-,13-12+/t17-,18+,19+,20-/m0/s1/i14D2,15D2. InChi Key: KEYDJKSQFDUAGF-GQTVQQAKSA-N.