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Cyclooxygenase metabolism of EPA to produce Prostaglandin E3 (PGE3) has been reported in biosynthetic preparations of ovine seminal vesicles and in the ocular tissues of primates. Prostaglandin A3 (PGA3) is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and EP4 receptors with IC50 values of 120 nM and 20 nM, respectively, in a radioligand binding assay. PGA3 has weak affinity for human PPARgamma, with a Ki value of 188 µM.Formal Name: 9-oxo-15S-hydroxy-prosta-5Z,10,13E,17Z-tetraen-1-oic acid. CAS Number: 36614-31-0. Synonyms: PGA3. Molecular Formula: C20H28O4. Formula Weight: 332.4. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 75 mg/ml, DMSO: 50 mg/ml, Ethanol: 100 mg/ml, PBS pH 7.2: 2.4 mg/ml. lambdamax: 216 nm. SMILES: O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C/C=C\CC)C=C1. InChi Code: InChI=1S/C20H28O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h3-4,6-7,12-18,21H,2,5,8-11H2,1H3,(H,23,24)/b6-3-,7-4-,14-12+/t16-,17-,18+/m0/s1. InChi Key: KSIRMUMXJFWKAC-FHJHOUOTSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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