Nepodin

Nepodin is a naphthol that has been found in Rumex and has diverse biological activities. It inhibits COX-1 and COX-2 in vitro (IC50s = 27.43 and 32.28 µM, respectively). Nepodin inhibits C. albicans and S. aureus biofilm formation in a concentration-dependent manner when used at concentrations ranging from 1 to 10 µM. It is active against chloroquine-sensitive and -resistant P. falciparum strains (IC50s = 0.74 and 0.79 µg/ml for strains 3D7 and S20, respectively). Nepodin (250 mg/kg) suppresses parasitemia and increases survival time in a mouse model of P. berghei infection. It also increases skeletal muscle phosphorylation of AMPK, reduces serum and hepatic triglyceride and cholesterol levels, and improves insulin resistance in db/db diabetic mice.Formal Name: 1-(1,8-dihydroxy-3-methyl-2-naphthalenyl)-ethanone. CAS Number: 3785-24-8. Synonyms: Musizin, NSC 365795. Molecular Formula: C13H12O3. Formula Weight: 216.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. lambdamax: 224, 260 nm. SMILES: CC(C(C(C)=O)=C1O)=CC2=C1C(O)=CC=C2. InChi Code: InChI=1S/C13H12O3/c1-7-6-9-4-3-5-10(15)12(9)13(16)11(7)8(2)14/h3-6,15-16H,1-2H3. InChi Key: DMLHPCALHMPJHS-UHFFFAOYSA-N. Origin: Plant/Maesopsis eminii/Dianella laevis/Dianella nigra/Rumex spp.