MF438

MF438 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1, IC50 = 2.3 nM for the rat enzyme), an enzyme that catalyzes the formation of a cis double bond at the ?9 position of stearoyl-CoA to produce oleoyl-CoA. It reduces spheroid formation in NCI H460 and patient-derived non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner, an effect that can be blocked by oleic acid (Cay-90260, Cay-24659). MF438 (1 µM) decreases the activity of aldehyde dehydrogenase 1A1 (ALDH1A1), a marker of cancer stem cells (CSCs), in NCI H460-derived spheroids when used at a concentration of 1 µM. It acts synergistically with cisplatin (Cay-13119) to induce apoptosis and autophagy in patient-derived NSCLC cells.Formal Name: 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-pyridazine. CAS Number: 921605-87-0. Molecular Formula: C19H18F3N5OS. Formula Weight: 421.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml. lambdamax: 224, 316 nm. SMILES: FC(F)(C1=C(OC2CCN(CC2)C3=CC=C(C4=NN=C(C)S4)N=N3)C=CC=C1)F. InChi Code: InChI=1S/C19H18F3N5OS/c1-12-23-26-18(29-12)15-6-7-17(25-24-15)27-10-8-13(9-11-27)28-16-5-3-2-4-14(16)19(20,21)22/h2-7,13H,8-11H2,1H3. InChi Key: NVUJDKDVOZVALT-UHFFFAOYSA-N.