LY255283

LY255283
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay70715-1 1 mg -

6 - 10 business days*

24.00€
Cay70715-5 5 mg -

6 - 10 business days*

95.00€
Cay70715-10 10 mg -

6 - 10 business days*

143.00€
Cay70715-25 25 mg -

6 - 10 business days*

268.00€
 
Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have... more
Product information "LY255283"
Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years. The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100 nM. LY255283 exhibits IC50 values of ~950 nM and >10 µM at human recombinant BLT2 and BLT1 receptors, respectively. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 µM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260 nM. Formal Name: 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone. CAS Number: 117690-79-6. Molecular Formula: C19H28N4O3. Formula Weight: 360.5. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 50 mg/ml, DMF:PBS (pH 7.2) (1:1): .1 mg/ml, DMSO: 30 mg/ml, Ethanol: 1 mg/ml. lambdamax: 213, 232, 276, 326 nm. SMILES: CCc1c(OCCCCCC(C)(C)c2nnn[nH]2)cc(O)cc1C(=O)C. InChi Code: InChI=1S/C19H28N4O3/c1-5-15-16(13(2)24)11-14(25)12-17(15)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23). InChi Key: VSDBVKWYFGKZPY-UHFFFAOYSA-N.
Keywords: 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone
Supplier: Cayman Chemical
Supplier-Nr: 70715

Properties

Application: BTL2 receptor antagonist
MW: 360.5 D
Formula: C19H28N4O3
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 117690-79-6| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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