IAXO-102

IAXO-102 is a glycolipid and an antagonist of toll-like receptor 4 (TLR4). It inhibits lipid A-induced TLR4 activation in a cell-based assay (IC50 = 5.013 µM). IAXO-102 (10 mg/kg) reduces LPS-induced lethality in mice. It decreases angiotensin II-induced aortic expansion and rupture, as well as the incidence of abdominal aortic aneurysms, in ApoE-/- mice when administered at a dose of 3 mg/kg.Formal Name: methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-alpha-D-glucopyranoside. CAS Number: 1115270-63-7. Molecular Formula: C35H71NO5. Formula Weight: 585.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. SMILES: CCCCCCCCCCCCCCO[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1OC)CN)O)OCCCCCCCCCCCCCC. InChi Code: InChI=1S/C35H71NO5/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-39-33-32(37)31(30-36)41-35(38-3)34(33)40-29-27-25-23-21-19-17-15-13-11-9-7-5-2/h31-35,37H,4-30,36H2,1-3H3/t31-,32-,33+,34-,35+/m1/s1. InChi Key: DJVFNDPRLMVKKO-KJQSSVQNSA-N.