Described to interfere with human, rat and mouse TLR4/CD14 signaling, other species not tested. Optimal working concentration depends upon the type, purity and concentration and of TLR4 ligand, carrier protein such as LPS-binding protein (LBP), soluble and membrane-bound CD14, the presence of TLR4 co-receptors (e.g....

IAXO-102 is a glycolipid and an antagonist of toll-like receptor 4 (TLR4). It inhibits lipid A-induced TLR4 activation in a cell-based assay (IC50 = 5.013 µM). IAXO-102 (10 mg/kg) reduces LPS-induced lethality in mice. It decreases angiotensin II-induced aortic expansion and rupture, as well as the incidence of...

Description: IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling by inhibiting MAPK and p65 NF-kappaB phosphorylation, as well as the expression of TLR4-dependent proinflammatory proteins. It also prevents the development of experimental abdominal aortic aneurysm. Target: TLR. Smiles: CCCCCCCCCC...