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The peroxisome proliferator-activated receptors (PPARs) alpha, gamma, and delta are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARalpha results in increased clearance of triglyceride (TG) rich very low-density lipoprotein (VLDL) via a reduction in plasma levels of ApoCIII and in upregulation of ApoA1, the principal lipoprotein component of HDL. GW 590735 is a potent and selective agonist of PPARalpha with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARgamma and PPARdelta.Formal Name: 2-methyl-2-[4-[[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]carbonyl]amino]methyl]phenoxy]-propanoic acid. CAS Number: 343321-96-0. Molecular Formula: C23H21F3N2O4S. Formula Weight: 478.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 0.25 mg/ml. lambdamax: 224, 311 nm. SMILES: O=C(NCc1ccc(cc1)OC(C)(C)C(=O)O)c1sc(nc1C)c1ccc(cc1)C(F)(F)F. InChi Code: InChI=1S/C23H21F3N2O4S/c1-13-18(33-20(28-13)15-6-8-16(9-7-15)23(24,25)26)19(29)27-12-14-4-10-17(11-5-14)32-22(2,3)21(30)31/h4-11H,12H2,1-3H3,(H,27,29)(H,30,31). InChi Key: ILUPZUOBHCUBKB-UHFFFAOYSA-N.
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