ER-819762

ER-819762 is an antagonist of the prostaglandin E2 (PGE2, Cay-14010) receptor subtype EP4 (IC50 = 70 nM). It is selective for EP4 over EP1, EP2, and EP3 in a cAMP reporter assay at 10 µM. ER-819762 reduces differentiation of mouse helper T cells when used at concentrations ranging from 0.1 to 10 nM and decreases IL-23 secretion by mouse dendritic cells from 0.04 to 5 nM. It also reduces the levels of Marek's disease virus (MDV) in chicken embryonic fibroblasts (CEFs) when used at a concentration of 1 µM. Oral administration of ER-819762 (30 and 100 mg/kg) prevents and reverses paw swelling, edema, and inflammation in a mouse model of rheumatoid arthritis induced by glucose-6-phosphate isomerase (GPI).Formal Name: (10S)-1'-[(3,5-dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methyl-spiro[1H-imidazo[1,5-b][2]benzazepine-1,4'-piperidin]-3(2H)-one. CAS Number: 1155773-15-1. Molecular Formula: C30H39N3O3. Formula Weight: 489.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 50 mg/ml. SMILES: O=C1N(CC)C2(CCN(CC3=CC(C)=CC(C)=C3)CC2)C4=C[C@H](C)C5=C(C=C(OC)C=C5OC)CN41. InChi Code: InChI=1S/C30H39N3O3/c1-7-33-29(34)32-19-24-16-25(35-5)17-26(36-6)28(24)22(4)15-27(32)30(33)8-10-31(11-9-30)18-23-13-20(2)12-21(3)14-23/h12-17,22H,7-11,18-19H2,1-6H3/t22-/m0/s1. InChi Key: ANKFBAJRCGOKJJ-QFIPXVFZSA-N.