DMHCA

DMHCA is a liver X receptor (LXR) agonist. It activates LXRalpha and LXRbeta in CV-1 cells expressing the human receptors in reporter assays (EC50 = 2 µM for both). DMHCA also inhibits ?24-dehydrocholesterol reductase (DHCR24, IC50 = 0.7 nM). It does not induce steatosis or increase liver triglyceride levels compared with the LXR agonist T0901317 (Cay-71810) in mice when administered at a dose of 80 mg/kg. DMHCA (8 mg/kg) reduces the size of atherosclerotic lesions in ApoE-/- mice fed a Western diet. It decreases proteinuria and hepatic cholesterol levels in a mouse model of diabetic nephropathy induced by streptozotocin (Cay-13104).Formal Name: (3beta)-3-hydroxy-N,N-dimethyl-chol-5-en-24-amide. CAS Number: 79066-03-8. Synonyms: Dimethyl-HCA, N,N-Dimethyl-3beta-hydroxycholenamide. Molecular Formula: C26H43NO2. Formula Weight: 401.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml. SMILES: C[C@@]12[C@](CC[C@]2([H])[C@@H](CCC(N(C)C)=O)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C. InChi Code: InChI=1S/C26H43NO2/c1-17(6-11-24(29)27(4)5)21-9-10-22-20-8-7-18-16-19(28)12-14-25(18,2)23(20)13-15-26(21,22)3/h7,17,19-23,28H,6,8-16H2,1-5H3/t17-,19+,20+,21-,22+,23+,25+,26-/m1/s1. InChi Key: NDGUBXOBXSPVHJ-LXVLQKCJSA-N.