ARN19874

ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD, IC50 = 33.7 µM). It is selective for NAPD-PLD over carbonic anhydrase II, neutral endopeptidase, and angiotensin-converting enzyme (ACE) up to 50 µM. ARN19874 (50 µM) increases the levels of certain NAPE substrates and decreases the endogenous levels of stearoyl ethanolamide (Cay-90245), but not oleoyl ethanolamide (Cay-90265) or palmitoyl ethanolamide (Cay-90350), in HEK293 cells.Formal Name: 1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(4-pyridinyl)phenyl]-6-quinazolinesulfonamide. CAS Number: 2190502-57-7. Molecular Formula: C19H14N4O4S. Formula Weight: 394.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml. lambdamax: 220, 264 nm. SMILES: O=C(NC(N1)=O)C2=C1C=CC(S(NC3=CC=C(C4=CC=NC=C4)C=C3)(=O)=O)=C2. InChi Code: InChI=1S/C19H14N4O4S/c24-18-16-11-15(5-6-17(16)21-19(25)22-18)28(26,27)23-14-3-1-12(2-4-14)13-7-9-20-10-8-13/h1-11,23H,(H2,21,22,24,25). InChi Key: OPBGIIQHYNFABO-UHFFFAOYSA-N.