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CL15F6
Item number: Cay40345-1
CL15F6 is an ionizable cationic lipid (pKa = 6.75). It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA and polymer-lipid hybrid nanoparticles for the delivery of plasmid DNA in vitro.Formal Name: 1-methyl-4-piperidinecarboxylic acid,...
| Keywords: | 1-methyl-4-piperidinecarboxylic acid, 11-[(2-hexyl-1-oxodecyl)oxy]-5-[6-[(2-hexyl-1-oxodecyl)oxy]hexyl]-5-hydroxyundecyl... |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2766493-40-5 |
| MW: | 906.5 D |
From 103.00€
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BAmP-O16B
Item number: Cay40473-10
BAmP-O16B is an ionizable cationic amino lipid that has been used in the generation of lipid nanoparticles (LNPs). LNPs containing BAmP-O16B and encapsulating NSA-inactivated RNase A reduce the viability of SiHa and HeLa cancer cells, but not non-cancerous NIH3T3 and HEK293T cells, upon intracellular reactivation of...
| Keywords: | bis(2-(dodecyldisulfaneyl)ethyl)... |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 1198 D |
From 176.00€
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PPPDA-O16B
Item number: Cay40517-10
PPPDA-O16B is a disulfide bond-containing ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for plasmid delivery in vitro and in vivo. LNPs containing PPPDA-O16B and encapsulating plasmids encoding Ras/Rap1-specific endopeptidase (RRSP) increase RRSP levels and decrease Ras...
| Keywords: | bis(2-(dodecyldisulfaneyl)ethyl) 3,3'-(propylazanediyl)dipropionate |
| Application: | Disulfide bond-containing ionizable cationic lipid, LNP formation |
| MW: | 724.2 D |
From 176.00€
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Loxoprofen-SRS
Item number: Cay38122-1
Loxoprofen-SRS is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.5 and 0.39 for recombinant human COX-1 and COX-2, respectively) and an active metabolite of the prodrug loxoprofen (Cay-35088). Intravenous administration of loxoprofen-SRS inhibits acetic acid-induced writhing, reduces...
| Keywords: | 4-[[(1R,2S)-2-hydroxycyclopentyl]methyl]-alphaS-methyl-benzeneacetic acid |
| Application: | NSAID, COX inhibitor, active loxoprofen metabolite |
| CAS | 83648-76-4 |
| MW: | 248.3 D |
From 38.00€
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CAP 2 (hydrochloride)
Item number: Cay38315-10
CAP 2 is an ionizable cationic lipid composed of two cholesterol moieties connected via a phosphate linker that contains an amino head group. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA or self-amplifying RNA (saRNA) in vivo. It has been used in the generation of lipid...
| Keywords: | CAP 2-4, Cholesterol-Amino-Phosphate 2,... |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 956.9 D |
From 157.00€
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DOSPA (hydrochloride)
Item number: Cay38585-1
DOSPA is a spermine-containing cationic lipid. It has been used in the formation of liposomes for the delivery of plasmid DNA in vitro. Transfection of liposomes containing DOSPA and encapsulating plasmid DNA encoding beta-galactosidase (beta-gal) increase beta-gal activity in NIH3T3 cells.Formal Name:...
| Keywords: | 2,3-Dioleyloxy-N-[2-(sperminecarboxamido)ethyl]-N,N-dimethyl-1-propanaminium,... |
| Application: | Cationic lipid, liposome formation |
| CAS | 282533-23-7 |
| MW: | 1073.8 D |
From 246.00€
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Gitoxin
Item number: Cay38888-1
Gitoxin is a cardiac glycoside originally found in Digitalis that has cardiotonic and antiarrhythmic activities. It inhibits Na+/K+-ATPase in an isoform-specific biphasic manner with IC50 values of 0.298 and 410 µM for the high- and low affinity human erythrocyte isoenzymes, respectively, and 1.18 and 28.5 µM for...
| Keywords: | NSC 95099,... |
| Application: | Cardiac glycoside, cardiotonic / antiarrhythmic agent |
| CAS | 4562-36-1 |
| MW: | 780.9 D |
From 38.00€
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9(S),12(S),13(S)-TriHODE
Item number: Cay38950-100
9(S),12(S),13(S)-TriHODE is an alpha-linolenic acid-derived oxylipin that has been found in C. olitorius. It is formed from alpha-linolenic acid (Cay-90210, Cay-21910) via a 9(S)-HpOTrE (Cay-45120) intermediate. Tumor levels of 9(S),12(S),13(S)-TriHODE are decreased compared with adjacent healthy tissue in dogs with...
| Keywords: | 9(S),12(S),13(S)-trihydroxy-trans-10,cis-15-Octadecadienoic Acid, 9(S),12(S),13(S)-trihydroxy-10(E),15(Z)-ODE,... |
| Application: | Oxylipin |
| CAS | 95341-44-9 |
| MW: | 328.4 D |
From 305.00€
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Cholesterol-PEG(2000)-Biotin
Item number: Cay39036-10
Cholesterol-PEG(2000)-biotin is a biotinylated and PEGylated form of cholesterol (Cay-9003100, Cay-39088). It has been used as a lipid anchor to immobilize vesicles, liposomes, viral particles, bacteria, or yeast to microfluidic chips. As a lipid anchor, cholesterol-PEG(2000)-biotin (10 µM) increases...
| Keywords: | Biotin-PEG2000-Cholesterol, CholBio2k,... |
| Application: | Biotinylated, PEGylated cholesterol, lipid anchor |
| MW: | 757.1 D |
From 44.00€
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Betamethasone Dipropionate
Item number: Cay39499-100
Betamethasone dipropionate is a synthetic corticosteroid and prodrug form of betamethasone (Cay-20363). It binds to the glucocorticoid receptor (IC50 = 5.25 nM). Betamethasone dipropionate decreases the number of circulating eosinophils in dogs and reduces croton oil-induced exudate formation in a granuloma pouch...
| Keywords: | Betamethasone 17,21-Dipropionate, SCH 11460, beta-Methasone Dipropionate,... |
| Application: | Betamethasone prodrug, synthetic corticosteroid |
| CAS | 5593-20-4 |
| MW: | 504.6 D |
From 58.00€
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IM21.7c
Item number: Cay39637-10
IM21.7c is a cationic lipid that has been used in the generation of lipid nanoparticles for the delivery of mRNA in vitro and in vivo. Intravenous administration of LNPs containing IM21.7c and encapsulating an mRNA reporter selectively accumulate in the lungs and spleen over the liver in mice.Formal Name:...
| Keywords: | 1-butyl-3-[1-(3,7-dimethyloctyl)-6-octadecyltetracosyl]-1H-imidazolium, monochloride |
| Application: | Cationic lipid, LNP formation |
| CAS | 2416939-42-7 |
| MW: | 890 D |
From 504.00€
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3-Phenylpropanoyl-Coenzyme A (sodium salt)
Item number: Cay39998-1
3-Phenylpropanoyl-coenzyme A (3-phenylpropanoyl-CoA) is a derivative of CoA (Cay-16147, Cay-21499, Cay-21722) that contains the medium-chain and phenyl-substituted fatty acid 3-phenylpropanoic acid. It has been used as an enzymatic substrate in potential screening assays for medium-chain acyl-CoA dehydrogenase...
| Keywords: | 3-Phenylpropanoyl-CoA, 3-Phenylpropionyl-CoA, 3-Phenylpropionyl-Coenzyme A, S-benzenepropanoate coenzyme A, sodium salt |
| Application: | Medium-chain, phenyl-substituted acyl CoA, MCAD screening enzymatic substrate |
| MW: | 899.7 D |
From 87.00€
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