DOSPA (hydrochloride)

DOSPA is a spermine-containing cationic lipid. It has been used in the formation of liposomes for the delivery of plasmid DNA in vitro. Transfection of liposomes containing DOSPA and encapsulating plasmid DNA encoding beta-galactosidase (beta-gal) increase beta-gal activity in NIH3T3 cells.Formal Name: N-[2-[[2,5-bis[(3-aminopropyl)amino]-1-oxopentyl]amino]ethyl]-N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanaminium, chloride, hydrochloride (1:1:4). CAS Number: 282533-23-7. Synonyms: 2,3-Dioleyloxy-N-[2-(sperminecarboxamido)ethyl]-N,N-dimethyl-1-propanaminium. Molecular Formula: C54H111N6O3 . Cl [4HCl]. Formula Weight: 1073.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble, Methanol: Slightly soluble. SMILES: CCCCCCCC/C=C\CCCCCCCCOC(COCCCCCCCC/C=C\CCCCCCCC)C[N+](C)(C)CCNC(C(NCCCN)CCCNCCCN)=O.[Cl-].Cl.Cl.Cl.Cl. InChi Code: InChI=1S/C54H110N6O3.5ClH/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-48-62-51-52(63-49-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2)50-60(3,4)47-46-59-54(61)53(58-45-39-42-56)40-37-43-57-44-38-41-55,,,,,/h19-22,52-53,57-58H,5-18,23-51,55-56H2,1-4H3,5*1H/b21-19-,22-20-,,,,,. InChi Key: RYQDMINLUXGGGS-AYXXFMLISA-N.