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PF-06446846 (hydrochloride)
Item number: Cay20914-10
PF-06446846 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) translation. It inhibits translation of mRNA encoding PCSK9 by isolated human ribosomes when used at a concentration of 100 µM. PF-06446846 also inhibits PCSK9 secretion by Huh7 cells (IC50 = 0. µM). In vivo, PF-06446846 (50 mg/kg)...
| Keywords: | N-(3-chloro-2-pyridinyl)-N-(3R)-3-piperidinyl-4-(3H-1,2,3-triazolo[4,5-b]pyridin-3-yl)-benzamide, hydrochloride |
| Application: | PCSK9 translation inhibitor |
| CAS | 1632250-50-0 |
| MW: | 433.9 D |
From 186.00€
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C2 Adamantanyl Galactosylceramide (d18:1/2:0)
Item number: Cay24472-1
C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease...
| Keywords: | AdaGalCer(d18:1/2:0), Admantanyl Galactosylceramide (d18:1/2:0), Admantanyl GalCer(d18:1/2:0), N-(1-adamantaneacetyl)... |
| Application: | Bioactive sphingolipid |
| CAS | 574738-16-2 |
| MW: | 637.89 D |
518.00€
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Palmitoyl-Coenzyme A (sodium salt)
Item number: Cay27703-1
Palmitoyl-coenzyme A (palmitoyl-CoA) is a derivative of CoA (Cay-16147, Cay-21499) that contains the saturated fatty acid palmitic acid (Cay-10006627, Cay-43561). It is a substrate for palmitoyltransferases during palmitoylation, a process that adds a palmitoyl group to proteins to anchor them to the membrane or...
| Keywords: | Hexadecanoyl-CoA, Palmitoyl-CoA |
| Application: | Long-chain saturated acyl CoA |
| MW: | 1005.94 D |
From 118.00€
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DMPE-mPEG(2000)
Item number: Cay34649-10
DMPE-mPEG(2000) is a PEGylated derivative of 1,2-dimyristoyl-sn-glycero-3-PE (DMPE). It has been used in the synthesis of nanostructured lipid carriers (NLCs) for use in ocular administration of ciprofloxacin (Cay-14286). SMILES: CCCCCCCCCCCCCC(O[C@@H](COP(OCCNC(OCCOC)=O)(O)=O)COC(CCCCCCCCCCCCC)=O)=O
| Keywords: | 1,2-Dimyristoyl-rac-glycero-3-PE-methoxy-Polyethyleneglycol-2000, 1,2-DMPE-MPEG(2000),... |
| Application: | DMPE PEGylated form |
| CAS | 261764-82-3 |
From 92.00€
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Methyl 13-cis-4-oxoretinoate
Item number: Cay38530-1
Methyl 13-cis-4-oxoretinoate is a degradation product of 13-cis retinoic acid (isotretinoin, Cay-21648). It is formed from 13-cis retinoic acid under acidic conditions. InChI: InChI=1S/C21H28O3/c1-15(8-7-9-16(2)14-20(23)24-6)10-11-18-17(3)19(22)12-13-21(18,4)5/h7-11,14H,12-13H2,1-6H3/b9-7+,11-10+,15-8+,16-14-,...
| Keywords: | Methyl 13-cis-4-oxo RA, Methyl 13-cis-4-oxo Retinoic Acid |
| Application: | 13-cis Retinoic acid degradation product |
| CAS | 71748-57-7 |
| MW: | 328.5 D |
From 127.00€
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1-Palmitoyl-2-Linoleoyl-sn-glycero-3-Phosphoglycerol
Item number: Cay38544-1
1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphoglycerol is a glycerophospholipid that contains palmitic acid (Cay-10006627, Cay-43561) and linoleic acid (Cay-90150, Cay-90150., Cay-21909) at the sn-1 and sn-2 positions, respectively. InChI:...
| Keywords: | 1,2-PLPG, 1-Hexadecanoyl-2-(9(Z)12(Z)-octadecadienoyl)-sn-glycero-3-phosphoglycerol, 1-Palmitoyl-2-linoleoyl... |
| Application: | Phospholipid |
| CAS | 322647-44-9 |
| MW: | 768.99 D |
From 49.00€
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Oleacein
Item number: Cay40719-5
Oleacein is a secoiridoid polyphenol that has been found in O. europea and has diverse biological activities. It inhibits 5-lipoxygenase (5-LO, IC50 = 2 µM for the human enzyme). Oleacein (20 and 50 µM) reduces lipid accumulation and inhibits the transition into foam cells in human monocyte-derived macrophages. It...
| Keywords: | (3S,4E)-4-formyl-3-(2-oxoethyl)-4-hexenoic acid, 2-(3,4-dihydroxyphenyl) ethyl ester |
| Application: | Bioactive secoiridoid polyphenol, weak 5-LO inhibitor |
| CAS | 149183-75-5 |
| MW: | 320.34 D |
483.00€
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Lucidenic Acid B
Item number: Cay43524-1
Lucidenic acid B is a triterpenoid that has been found in G. lucidum and has anticancer activity. It inhibits Epstein-Barr virus early antigen production induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in Raji Burkitt lymphoma cells. Lucidenic acid B inhibits the growth of COLO 205, HepG2, HL-60, and...
| Keywords: | (5alpha,7beta,12beta)-7,12-dihydroxy-4,4,14-trimethyl-3,11,15-trioxo-chol-8-en-24-oic acid |
| Application: | Bioactive triterpenoid, anticancer agent |
| CAS | 95311-95-8 |
| MW: | 474.59 D |
From 260.00€
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DMA4-H228
Item number: Cay43807-1
DMA4-H228 is an ionizable cationic lipidoid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing DMA4-H228 selectively accumulate in antigen-presenting cells in the spleen in mice. DMA4-H228-containing LNPs encapsulating mRNA encoding ovalbumin induce...
| Keywords: | ((3,3'-((2-(1-methylpyrrolidin-2-yl)ethyl)azanediyl)bis(propanoyl))bis(oxy))bis(ethane-2,1-diyl)... |
| Application: | Ionizable cationic lipidoid, LNP generation |
| CAS | 3091917-64-2 |
| MW: | 1007.49 D |
From 53.00€
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Lipid C16-C
Item number: Cay44085-1
Lipid C16-C is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing lipid C16-C selectively traffic to mouse liver and spleen over the lungs, kidneys, lymph nodes, and heart. LNPs containing lipid C16-C and...
| Keywords: | 17-(2-(4-(2-(2-(2-(bis(2-hydroxyhexadecyl)amino)ethoxy)ethoxy)ethyl)piperazin-1-yl)ethyl)-26-(2-hydroxyhexadecyl)-20,23-di... |
| Application: | Ionizable cationic lipid, LNP generation |
| CAS | 2639634-86-7 |
| MW: | 1593.71 D |
From 157.00€
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CF3-2N6-UC18
Item number: Cay44140-1
CF3-2N6-UC18 is an ionizable cationic and chloroquine-derived lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing CF3-2N6-UC18 and encapsulating a Cy5-mRNA reporter exhibit increased cellular uptake via micropinocytosis and improved...
| Keywords: | N1,N1-di-9-octadecen-1-yl-N6-[7-(trifluoromethyl)-4-quinolinyl]-1,6-hexanediamine |
| Application: | Ionizable cationic, chloroquine-derived lipid, LNP generation |
| MW: | 812.29 D |
From 88.00€
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Lipid TD5
Item number: Cay44285-1
Lipid TD5 is an ionizable cationic lipid (pKa = 7.3) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing lipid TD5 undergo endocytosis in a serotonin (5-HT) receptor subtype 1A-dependent manner in primary mouse astrocytes. Intrathecal...
| Keywords: | N-[6-(ditetradecylamino)hexyl]-1H-indole-3-propanamide |
| Application: | Ionizable cationic lipid, LNP generation |
| CAS | 2855180-86-6 |
| MW: | 680.16 D |
From 73.00€
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