DMA4-H228
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
DMA4-H228 is an ionizable cationic lipidoid that has been used in the generation of lipid... more
Product information "DMA4-H228"
DMA4-H228 is an ionizable cationic lipidoid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing DMA4-H228 selectively accumulate in antigen-presenting cells in the spleen in mice. DMA4-H228-containing LNPs encapsulating mRNA encoding ovalbumin induce activation of splenic antigen-presenting cells and increase serum levels of IFN-alpha in mice. LNPs containing DMA4-H228 and encapsulating mRNA encoding ovalbumin decrease tumor volume and increase intratumoral CD8+ T cells and serum anti-ovalbumin IgG titers in a B16/F10-OVA murine melanoma model. InChI: InChI=1S/C57H106N4O10/c1-6-10-14-18-22-26-40-60(41-27-23-19-15-11-7-2)52(62)32-34-54(64)68-47-49-70-56(66)37-45-59(44-36-51-31-30-39-58(51)5)46-38-57(67)71-50-48-69-55(65)35-33-53(63)61(42-28-24-20-16-12-8-3)43-29-25-21-17-13-9-4/h51H,6-50H2,1-5H3, InChIKey: OPRKPOFEXCTWIG-UHFFFAOYSA-N, SMILES: CCCCCCCCN(C(CCC(OCCOC(CCN(CCC1N(C)CCC1)CCC(OCCOC(CCC(N(CCCCCCCC)CCCCCCCC)=O)=O)=O)=O)=O)=O)CCCCCCCC
| Keywords: | ((3,3'-((2-(1-methylpyrrolidin-2-yl)ethyl)azanediyl)bis(propanoyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-(dioctylamino)-4-oxobutanoate) |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 43807 |
Properties
| Application: | Ionizable cationic lipidoid, LNP generation |
| MW: | 1007.49 D |
| Formula: | C57H106N4O10 |
| Purity: | >95% |
| Format: | Solution |
Database Information
| CAS : | 3091917-64-2| Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H400, H410 |
| P Phrases: | P264, P270, P273, P301+310, P330, P391, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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