CF3-2N6-UC18

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
Cay44140-1	1 mg		-		6 - 10 business days*		88.00€
Cay44140-5	5 mg		-		6 - 10 business days*		415.00€

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CF3-2N6-UC18 is an ionizable cationic and chloroquine-derived lipid that has been used in the... more

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Product information "CF3-2N6-UC18"

CF3-2N6-UC18 is an ionizable cationic and chloroquine-derived lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing CF3-2N6-UC18 and encapsulating a Cy5-mRNA reporter exhibit increased cellular uptake via micropinocytosis and improved endosomal escape compared with LNPs containing non-chloroquine-derived lipids. LNPs containing CF3-2N6-UC18 selectively accumulate in mouse lymph nodes after intravenous administration. InChI: InChI=1S/C52H88F3N3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-32-36-44-58(45-37-33-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)46-38-34-31-35-42-56-50-41-43-57-51-47-48(52(53,54)55)39-40-49(50)51/h17-20,39-41,43,47H,3-16,21-38,42,44-46H2,1-2H3,(H,56,57)/b19-17-,20-18-, InChIKey: RQICHMVWIDRVQC-CLFAGFIQSA-N, SMILES: CCCCCCCC/C=C\CCCCCCCCN(CCCCCCCC/C=C\CCCCCCCC)CCCCCCNC1=C(C=CC(C(F)(F)F)=C2)C2=NC=C1

Keywords:	N1,N1-di-9-octadecen-1-yl-N6-[7-(trifluoromethyl)-4-quinolinyl]-1,6-hexanediamine
Supplier:	Cayman Chemical
Supplier-Nr:	44140

Properties

Application:	Ionizable cationic, chloroquine-derived lipid, LNP generation
MW:	812.29 D
Formula:	C52H88F3N3
Purity:	>90%
Format:	Liquid

Database Information

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: -20°C)
Signal Word:	Warning
GHS Hazard Pictograms:
H Phrases:	H302, H400, H410
P Phrases:	P264, P270, P273, P301+310, P330, P391, P501