8-iso Prostaglandin F2alpha-d4

8-iso Prostaglandin F2alpha-d4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay316350-25 25 µg -

6 - 10 business days*

Cay316350-50 50 µg -

6 - 10 business days*

Cay316350-100 100 µg -

6 - 10 business days*

8-iso PGF2alpha-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is... more
Product information "8-iso Prostaglandin F2alpha-d4"
8-iso PGF2alpha-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-iso PGF2alpha by GC- or LC-mass spectrometry. 8-iso Prostaglandin F2alpha (8-iso PGF2alpha) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It circulates in human plasma in two distinct forms - esterified in LDL phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2alpha level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2alpha levels are about 180-200 pg/mg of creatinine. 8-iso PGF2alpha is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF2alpha inhibits platelet aggregation induced by U-46619 (10-6 M) and I-BOP (3 x 10-7 M) with IC50 values of 1.6 x 10-6 M and 1.8 x 10-6 M, respectively. Formal Name: 9alpha,11alpha,15S-trihydroxy-(8beta)-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid. CAS Number: 211105-40-7. Synonyms: iPF2alpha-III-d4, 8-Isoprostane-d4, 15-F2t-Isoprostane-d4, 8-epi PGF2alpha-d4. Molecular Formula: C20H30D4O5. Formula Weight: 358.5. Purity: >99% deuterated forms (d1-d4). Formulation: A solution in methyl acetate. Solubility: 10 mM Na2CO3: >6.5 mg/ml (from PGF2a), DMF: >100 mg/ml (from PGF2a), DMSO: >100 mg/ml (from PGF2a), Ethanol: >100 mg/ml (from PGF2a), PBS pH 7.2: >10 mg/ml (from PGF2a). SMILES: O[C@@H]1[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)[C@H](O)C1. InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17+,18-,19+/m0/s1/i5D2,8D2. InChi Key: PXGPLTODNUVGFL-FLRLWOSLSA-N.
Keywords: 15-F2t-Isoprostane-d4, 8-epi PGF2alpha-d4, 8-Isoprostane-d4, iPF2alpha-III-d4, 9alpha,11alpha,15S-trihydroxy-(8beta)-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid
Supplier: Cayman Chemical
Supplier-Nr: 316350


Application: Standard
MW: 358.5 D
Formula: C20H30D4O5
Purity: >99% deuterated forms (d1-d4)
Format: Solution

Database Information

CAS : 211105-40-7| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H319, H336
P Phrases: , P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
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