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Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors - LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23. OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA3) receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA1 and LPA2-expressing Sf9 cells, respectively. The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells.Formal Name: 9Z-octadecenoic acid, (2S)-3-[(hydroxymercaptophosphinyl)oxy]-2-methoxypropyl ester, triethyl ammonium salt (1:2). CAS Number: 1217471-69-6. Molecular Formula: C22H43O6PS . 2(C2H5)3N. Formula Weight: 669.0. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol:chloroform (1:1). Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(OC[C@H](OC)COP(O)(O)=S)CCCCCCC/C=C\CCCCCCCC. InChi Code: InChI=1S/C22H43O6PS/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22(23)27-19-21(26-2)20-28-29(24,25)30/h10-11,21H,3-9,12-20H2,1-2H3,(H2,24,25,30)/b11-10-/t21-/m0/s1. InChi Key: FCVJYKICQNLXAX-XPTLAUCJSA-N.
Keywords:
9Z-octadecenoic acid, (2S)-3-[(hydroxymercaptophosphinyl)oxy]-2-methoxypropyl ester, triethyl ammonium salt (1:2)
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