15(R)-17-phenyl trinor Prostaglandin F2alpha

15(R)-17-phenyl trinor Prostaglandin F2alpha
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16814-1 1 mg -

6 - 10 business days*

64.00€
Cay16814-5 5 mg -

6 - 10 business days*

288.00€
Cay16814-10 10 mg -

6 - 10 business days*

510.00€
 
17-phenyl trinor Prostaglandin F2alpha N-ethyl amide (17-phenyl trinor PGF2alpha) is an F-series... more
Product information "15(R)-17-phenyl trinor Prostaglandin F2alpha"
17-phenyl trinor Prostaglandin F2alpha N-ethyl amide (17-phenyl trinor PGF2alpha) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2alpha ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2alpha ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 µg/cornea/24 hours. The free acid, 17-phenyl trinor PGF2alpha, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2alpha is the 15-epi, or "unnatural" isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. Formal Name: 9alpha,11alpha,15R-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid. CAS Number: 41639-71-8. Synonyms: 15-epi Bimatoprost (free acid), 15(R)-Bimatoprost (free acid), 15(R)-17-phenyl trinor PGF2alpha. Molecular Formula: C23H32O5. Formula Weight: 388.5. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@H](O)CCC2=CC=CC=C2)[C@H](O)C1. InChi Code: InChI=1S/C23H32O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-22,24-26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19-,20-,21+,22-/m1/s1. InChi Key: YFHHIZGZVLHBQZ-MTDOSWCTSA-N.
Keywords: 15(R)-17-phenyl trinor PGF2alpha, 15(R)-Bimatoprost (free acid), 15-epi Bimatoprost (free acid), 9alpha,11alpha,15R-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 16814

Properties

Application: Bioactive lipid assays
MW: 388.5 D
Formula: C23H32O5
Purity: >98%
Format: Solution

Database Information

CAS : 41639-71-8| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336, H360
P Phrases: P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P308+313, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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