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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay12720-500 | 500 µg | - |
6 - 10 business days* |
105.00€
|
|||
Cay12720-1 | 1 mg | - |
6 - 10 business days* |
177.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic... more
Product information "15(R)-15-methyl Prostaglandin D2"
15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 (Cay-12010). The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.Formal Name: 9alpha,15R-dihydroxy-11-oxo-15-methyl-prosta-5Z,13E-dien-1-oic acid. CAS Number: 210978-26-0. Synonyms: 15(R)-15-methyl PGD2. Molecular Formula: C21H34O5. Formula Weight: 366.5. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >100 mg/ml, DMSO: >50 mg/ml, Ethanol: >75 mg/ml, PBS (pH 7.2): >5 mg/ml. SMILES: CCCCC[C@@](C)(O)\C=C\[C@H]1C(=O)CC(O)C1C/C=C\CCCC(=O)O. InChi Code: InChI=1S/C21H34O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-18,22,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5-,14-12+/t16-,17-,18+,21-/m1/s1. InChi Key: CTXLUMAOXBULOZ-BKVRKCTKSA-N.
Keywords: | 15(R)-15-methyl PGD2, 9alpha,15R-dihydroxy-11-oxo-15-methyl-prosta-5Z,13E-dien-1-oic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 12720 |
Properties
Application: | CRTH2 receptor agonist, DP2 receptor agonist |
MW: | 366.5 D |
Formula: | C21H34O5 |
Purity: | >95% |
Format: | Solution |
Database Information
CAS : | 210978-26-0| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H225, H319, H333, H336, H360 |
P Phrases: | P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+312, P304+340, P305+351+338, P308+313, P312, P337+313, P370+378, P403+233, P403+235, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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