15(R)-15-methyl Prostaglandin D2

15(R)-15-methyl Prostaglandin D2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay12720-500 500 µg -

3 - 10 business days*

Cay12720-1 1 mg -

3 - 10 business days*

Cay12720-5 5 mg -

3 - 10 business days*

15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic... more
Product information "15(R)-15-methyl Prostaglandin D2"
15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 (Cay-12010). The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1 and CRTH2/DP2. 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.
Keywords: 15(R)-15-methyl PGD2, 9alpha,15R-dihydroxy-11-oxo-15-methyl-prosta-5Z,13E-dien-1-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 12720-500


Application: CRTH2 receptor agonist, DP2 receptor agonist
MW: 366.5 D
Formula: C21H34O5
Purity: >95%
Format: Solution

Database Information

CAS : 210978-26-0| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336, H360, EUH066
P Phrases: P201, P202, P210, P240, P241, P242, P243, P261, P264, P271, P280, P312, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P337+P313, P370+P378, P405, P403+P233, P403+P235, P501
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