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Product information "1-Oleoyl-2-hydroxy-sn-glycero-3-PA (sodium salt)"
1-Oleoyl-2-hydroxy-sn-glycero-3-PA is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by phosphorylation of DAG by diglycerol kinase. Hydrolysis of the fatty acid at the sn-2 position by PLA2 yields bioactive LPA. LPA binds to one of four different G-protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. 1-Oleoyl-2-hydroxy-sn-glycero-3-PA is the most potent of the LPA analogs for calcium mobilization in A431 cells and for growth stimulation of a variety of cell lines.Formal Name: 9Z-octadecenoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester, monosodium salt. CAS Number: 325465-93-8. Synonyms: PA(18:1/0:0), 18:1 LPA, LPA 18:1, 1-Octadecenoyl-2-hydroxy-sn-glycero-3-phosphate, 1-Oleoyl LPA, 1-Oleoyl Lysophosphatidic Acid. Molecular Formula: C21H40O7P . Na. Formula Weight: 458.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 µg/ml, DMSO: 50 µg/ml, EtOH: 50 µg/ml, PBS, pH 7.2: 8.3 mg/ml. SMILES: CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](O)COP([O-])(O)=O)=O.[Na+]. InChi Code: InChI=1S/C21H41O7P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26,/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26),/q,+1/p-1/b10-9-,/t20-,/m1./s1. InChi Key: XGRLSUFHELJJAB-JGSYTFBMSA-M. Side Chain Carbon Sum: 18:1.
Keywords:
Oleoyl-sn-3-glycerophosphate, 9Z-octadecenoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester, monosodium salt
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