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Product information "Ursodeoxycholic Acid (sodium salt)"
Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA, Cay-10011286). UDCA is also a metabolite of lithocholic acid (LCA, Cay-20253) in human liver microsomes. It inhibits taurocholic acid (Cay-16215) uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 µM. UDCA (50 µM) inhibits apoptosis induced by deoxycholic acid (DCA, Cay-20756, Cay-18231) or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.Formal Name: 3alpha,7beta-dihydroxy-5beta-cholan-24-oic acid, sodium salt. CAS Number: 31687-65-7. Synonyms: UDCA, Ursodiol. Molecular Formula: C24H39O4 . xNa. Formula Weight: 414.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, Ethanol: 15 mg/ml. SMILES: [O-]C(CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=O.[Na]. InChi Code: InChI=1S/C24H40O4.Na/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26,/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28),/p-1/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-,/m1./s1. InChi Key: DOVZGADDWOFQEZ-FUXQPCDDSA-M.
Keywords:
UDCA, Ursodiol, (3alpha,5beta,7beta)-3,7-dihydroxy-cholan-24-oic acid, monosodium salt
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