YW2065

YW2065 is an inhibitor of Wnt/beta-catenin signaling and an activator of AMP-activated protein kinase (AMPK). It induces degradation of beta-catenin and increases the levels of Axin1 and phosphorylated AMPK and acetyl-CoA carboxylase (ACC), which is a downstream substrate of AMPK, in SW620 colorectal cancer cells when used at a concentration of 3 µM. YW2065 inhibits recombinant human Wnt3a-induced reporter activation in HEK293 cells (IC50 = 2.3 nM) and the growth of SW480 colorectal cancer cells (GI50 = 2.4 nM). In vivo, YW2065 (50 mg/kg) decreases tumor volume and weight in an SW620 mouse xenograft model. SMILES O=C(C1=C(C)N(C2=CC=CC=C2Br)N=C1)NC3=CC=C4C=CC=CC4=N3 InChi Code InChI=1S/C20H15BrN4O/c1-13-15(12-22-25(13)18-9-5-3-7-16(18)21)20(26)24-19-11-10-14-6-2-4-8-17(14)23-19/h2-12H,1H3,(H,23,24,26) InChi Key ATYUYECWVYSPBS-UHFFFAOYSA-N