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Survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and cancer cell survival in many types of cancer. YM-155 is a novel small molecule that suppresses transactivation of survivin through direct binding to its promoter. It selectively suppresses expression of survivin and induces apoptosis in p53-deficient cancer cells in vitro at 10 nM. At concentrations up to 100 nM, YM-155 has little effect on expression levels of other IAP- or Bcl-2-related proteins. YM-155 exerts anti-tumor effects in various in vivo cancer models, including prostate, pancreatic, and lung cancer.Formal Name: 4,9-dihydro-1-(2-methoxyethyl)2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium, bromide. CAS Number: 781661-94-7. Synonyms: Sepantronium bromide. Molecular Formula: C20H19N4O3 . Br. Formula Weight: 443.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 246, 252, 271, 344 nm. SMILES: O=C(C1=C2N(CCOC)C(C)=[N+]1CC3=CN=CC=N3)C4=CC=CC=C4C2=O.[Br-]. InChi Code: InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25,/h3-8,11H,9-10,12H2,1-2H3,1H/q+1,/p-1. InChi Key: QBIYUDDJPRGKNJ-UHFFFAOYSA-M.
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