YKL-5-124

A Cdk7 inhibitor (IC50 = 9.7 nM), selective for Cdk7 over Cdk2 and Cdk9 (IC50s = 1,300 and 3,020 nM, respectively), induces cell cycle arrest at G1 and G2 phases in HAP1 cells at 60 nM, inhibits HIV-1 provirus expression in HIV-1-infected J-Lat 10.6 cells at 100 nM, decreases tumor volume and increases survival in combination with JQ1 in a PDX mouse model of neuroblastoma at 2.5 mg/kg per day