71 products were found matching "K02202"!

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Anti-CDK7
Anti-CDK7

Item number: A300-405A

Protein function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin- dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2...
Keywords: Anti-CAK, Anti-CDK7, Anti-p39 Mo15, EC=2.7.11.22, EC=2.7.11.23, Anti-39 kDa protein kinase, Anti-CDK-activating kinase 1,...
Application: WB, IP, IHC, ICC
Host: Rabbit
Species reactivity: human, mouse, rat
From 164.00€ *
Review
THZ1
THZ1

Item number: Cay9002215-1

THZ1 is a Cdk7 inhibitor (IC50s = 3.2-15.6 nM in vitro) that selectively targets a remote cysteine residue located outside of the classic kinase domain. THZ1 also targets Cdk12 kinase activity although at a higher concentration (IC50 = 250 nM). It displays broad anti-proliferative activity against cancer cell lines,...
Keywords: N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-benzamide
Application: CDK7 inhibitor
CAS 1604810-83-4
MW: 566.1 D
From 48.00€ *
Review
Flavopiridol
Flavopiridol

Item number: Cay26024-5

Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa...
Keywords: Alvocidib, HL 275, HMR 1275, L-868,275,...
Application: Cyclin dependent kinase inhibitor
CAS 146426-40-6
MW: 401.8 D
From 77.00€ *
Review
SNS-032
SNS-032

Item number: Cay17904-5

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively. It is selective for these kinases and displays no additional activity...
Keywords: BMS-387032, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
Application: Cdk9 / Cdk2 / Cdk7 inhibitor
CAS 345627-80-7
MW: 380.5 D
From 60.00€ *
Review
LDC-4297
LDC-4297

Item number: Cay23398-1

LDC-4297 is an inhibitor of cyclin-dependent kinase 7 (CDK7, IC50 = 50s = >10, >10, and 1.71 µM), however, it also inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively). LDC-4297 (10-100 nM) induces apoptosis in A549, HeLa, and HCT116 cancer cells in a concentration-dependent manner. It inhibits human...
Keywords: 8-(1-methylethyl)-2-(3-piperidinyloxy)-N-[[2-(1H-pyrazol-1-yl)phenyl]methyl]-pyrazolo[1,5-a]-1,3,5-triazin-4-amine
Application: CDK7 inhibitor
CAS 1453834-21-3
MW: 432.5 D
From 50.00€ *
Review
BS-181 (hydrochloride)
BS-181 (hydrochloride)

Item number: Cay17996-10

BS-181 is a Cdk7 inhibitor that blocks the activity of Cdk-activating kinase with an IC50 value of 21 nM. It inhibits Cdk2 at a concentration 35-fold higher than that of Cdk7. BS-181 has been shown to inhibit the phosphorylation of Cdk7 substrates, to promote cell cycle arrest and apoptosis, to inhibit the growth of...
Keywords: N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-pyrazolo[1,5-alpha]pyrimidine-5,7-diamine, monohydrochloride
Application: CDK7 inhibitor
CAS 1397219-81-6
MW: 417 D
From 60.00€ *
Review
ICEC0942 (hydrochloride)
ICEC0942 (hydrochloride)

Item number: Cay30997-1

ICEC0942 is a cyclin-dependent kinase 7 (Cdk7) inhibitor (IC50 = 0.04 µM). It is selective for Cdk7 over Cdk1, -2, -4, -5, -6, and -9 (IC50s = 1.8, 0.62, 49, 9.4, 34, and 1.2 µM, respectively). ICEC0942 induces cell cycle arrest at the G2/M phase and apoptosis in HCT116 cells when used at concentrations of 1 and 10...
Keywords: (3R,4R)-4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-3-piperidinol,...
Application: Cdk7 inhibitor
CAS 1805789-54-1
MW: 431 D
From 62.00€ *
Review
Anti-CDK7 Recombinant Monoclonal
Anti-CDK7 Recombinant Monoclonal

Item number: A700-006

Protein function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin- dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2...
Keywords: Anti-CAK, Anti-CDK7, Anti-p39 Mo15, EC=2.7.11.22, EC=2.7.11.23, Anti-39 kDa protein kinase, Anti-CDK-activating kinase 1,...
Application: WB, IP, IHC, ICC, FC
Host: Rabbit
Species reactivity: human
From 172.00€ *
Review
Human Cdk7 ELISA Kit
Human Cdk7 ELISA Kit

Item number: G-HUFI02303.96

Application: ELISA
Species reactivity: human
641.00€ *
Review
Anti-Cdk7
Anti-Cdk7

Item number: NSJ-R31240

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cyclin-dependent kinase 7, also known as Cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase(CDK) family. The gene was assigned to human...
Keywords: Anti-CAK, Anti-CDK7, Anti-p39 Mo15, EC=2.7.11.22, EC=2.7.11.23, Anti-39 kDa protein kinase, Anti-CDK-activating kinase 1,...
Application: WB
Host: Rabbit
Species reactivity: human, rat, mouse
755.00€ *
Review
Anti-Cdk7
Anti-Cdk7

Item number: NSJ-R31241

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cyclin-dependent kinase 7, also known as cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase(CDK) family. The gene was assigned to human...
Keywords: Anti-Cak, Anti-Cdk7, Anti-CRK4, Anti-P39 Mo15, EC=2.7.11.22, EC=2.7.11.23, Anti-CR4 protein kinase, Anti-39 kDa protein...
Application: WB
Host: Rabbit
Species reactivity: human, rat, mouse
755.00€ *
Review
Anti-Cdk7
Anti-Cdk7

Item number: NSJ-R32121

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cyclin-dependent kinase 7, also known as cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. The gene was assigned to human...
Keywords: Anti-CAK, Anti-CDK7, Anti-p39 Mo15, EC=2.7.11.23, EC=2.7.11.22, Anti-39 kDa protein kinase, Anti-CDK-activating kinase 1,...
Application: WB
Host: Rabbit
Species reactivity: human
755.00€ *
Review
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