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YKL-5-124
Item number: Cay31057-1
A Cdk7 inhibitor (IC50 = 9.7 nM), selective for Cdk7 over Cdk2 and Cdk9 (IC50s = 1,300 and 3,020 nM, respectively), induces cell cycle arrest at G1 and G2 phases in HAP1 cells at 60 nM, inhibits HIV-1 provirus expression in HIV-1-infected J-Lat 10.6 cells at 100 nM, decreases tumor volume and increases survival in...
| Keywords: | N-[(1S)-2-(dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]-pyrrolo... |
| Application: | Cdk7 inhibitor |
| CAS | 1957203-01-8 |
| MW: | 515.61 D |
From 40.00€
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YKL-5-124
Item number: TGM-T22461-100mg
Description: YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13. Target: CDK. Smiles:...
| CAS | 1957203-01-8 |
| MW: | 515.61 D |
From 91.00€
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