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Item number: Cay45487-1

YIC-C8-434 is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT, IC50 = 11 nM in isolated rat hepatic microsomes). It reduces plasma cholesterol levels by 79% in rats when administered at a dose of 0.005% in a high-cholesterol diet. Oral administration of YIC-C8-434 (8.3 mg/kg per day) reduces cholesterol...

Keywords:	(2E)-3-[3,5-dimethoxy-4-(octyloxy)phenyl]-1-[4-(3,4-dimethylphenyl)-1-piperazinyl]-2-propen-1-one
Application:	ACAT inhibitor
CAS	214265-97-1
MW:	508.7 D

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