VER-246608

Item number	Size	Delivery time	Price
TGM-T17224-1mg	1 mg	7 - 10 business days*	48.00€
TGM-T17224-2mg	2 mg	7 - 10 business days*	67.00€
TGM-T17224-5mg	5 mg	7 - 10 business days*	112.00€
TGM-T17224-1mL	1 ml	7 - 10 business days*	139.00€
TGM-T17224-10mg	10 mg	7 - 10 business days*	176.00€
TGM-T17224-25mg	25 mg	7 - 10 business days*	345.00€
TGM-T17224-50mg	50 mg	7 - 10 business days*	527.00€
TGM-T17224-100mg	100 mg	7 - 10 business days*	768.00€

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Description: VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase... more

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Product information "VER-246608"

Description: VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin. Target: Dehydrogenase, PDK. Smiles: Cc1cnc(Cl)nc1-c1ccc(cc1)N(Cc1ccc(CNC(=O)C(F)F)cc1)C(=O)c1ccc(O)cc1O

Supplier:	TargetMol
Supplier-Nr:	T17224

Properties

Application:	PDK1/2/3/4 inhibitor
MW:	552.96 D
Formula:	C28H23ClF2N4O4

Database Information

CAS :	1684386-71-7\| Matching products
KEGG ID :	K00898 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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