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VER-246608
Item number: BPS-82820-1
VER-246608 is a potent and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively.1
| Keywords: | PDK inhibitor, pyruvate dehydrogenase kinase inhibitor, |
| Application: | PDK (pyruvate dehydrogenase kinase) inhibitor |
| CAS | 1684386-71-7 |
| MW: | 552,96 D |
From 485.00€
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VER-246608
Item number: TGM-T17224-100mg
Description: VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK...
| Application: | PDK1/2/3/4 inhibitor |
| CAS | 1684386-71-7 |
| MW: | 552.96 D |
From 48.00€
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VER-246608
Item number: Cay19182-1
VER-246608 is a pan-inhibitor of pyruvate dehydrogenase kinase (PDHK, IC50s = 35, 84, 40, and 91 nM for PDHK1, -2, -3, and -4, respectively). It is selective for PDHKs over heat shock protein 90 (Hsp90, IC50 = >100 µM), as well as a panel of 97 kinases at 10 µM. VER-246608 (10 and 20 µM) decreases the production of...
| Keywords: | N-[4-(2-chloro-5-methyl-4-pyrimidinyl)phenyl]-N-[[4-[[(2,2-difluoroacetyl)amino]methyl]phenyl]methyl]-2,4-dihydroxy-benzamide |
| Application: | PDK1/2/3/4 inhibitor |
| CAS | 1684386-71-7 |
| MW: | 553 D |
From 45.00€
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