UNC6934

UNC6934 is an inhibitor of the protein-protein interaction between histone-lysine N-methyltransferase NSD2 and dimethylated lysine 36 histone 3 (H3K36me2) nucleosomes (IC50 = 104 nM). It binds to NSD2 (Kd = 92 nM). UNC6934 also inhibits the serotonin transporter (SERT) and µ-opioid receptor (Kis = 1.4 and 8 µM, respectively). It induces NSD2 nucleolus accumulation in U2OS cells when used at a concentration of 5 µM.Formal Name: N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide. CAS Number: 2561494-77-5. Molecular Formula: C24H21N5O4. Formula Weight: 443.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: O=C(N1)COC2=C1C=CC(C(N(C3CC3)CC4=CC=C(C(NC5=NC=NC=C5)=O)C=C4)=O)=C2. InChi Code: InChI=1S/C24H21N5O4/c30-22-13-33-20-11-17(5-8-19(20)27-22)24(32)29(18-6-7-18)12-15-1-3-16(4-2-15)23(31)28-21-9-10-25-14-26-21/h1-5,8-11,14,18H,6-7,12-13H2,(H,27,30)(H,25,26,28,31). InChi Key: KOZGEDUWAQFVAV-UHFFFAOYSA-N.