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Item number: TGM-T9584-1mg

Description: UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. Target: Histone Methyltransferase, HIF/HIF Prolyl-Hydroxylase. Smiles: O=C(Nc1ccncn1)c1ccc(CN(C2CC2)C(=O)c2ccc3NC(=O)COc3c2)cc1. References: Dilworth D, et al. A chemical probe targeting the PWWP domain alters NSD2...

Application:	NSD2-H3K36me2 nucleosome interaction inhibitor
CAS	2561494-77-5
MW:	443.45 D

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UNC6934

Item number: Cay28814-10

UNC6934 is an inhibitor of the protein-protein interaction between histone-lysine N-methyltransferase NSD2 and dimethylated lysine 36 histone 3 (H3K36me2) nucleosomes (IC50 = 104 nM). It binds to NSD2 (Kd = 92 nM). UNC6934 also inhibits the serotonin transporter (SERT) and µ-opioid receptor (Kis = 1.4 and 8 µM,...

Keywords:	N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide
Application:	NSD2-H3K36me2 nucleosome interaction inhibitor
CAS	2561494-77-5
MW:	443.5 D

From 88.00€ *

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