UK 371804

UK 371804 is an inhibitor of urokinase-type plasminogen activator (uPA, Ki = 10 nM). It is 4,000- and 2,700-fold selective for uPA over tissue plasminogen activator (tPA) and plasmin, respectively. UK 371804 inhibits exogenous uPA in human chronic wound fluid (IC50 = 0.89 µM). Topical administration of UK 371804 inhibits exogenous uPA activity in a porcine excisional wound model.Formal Name: N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-alanine. CAS Number: 256477-09-5. Molecular Formula: C14H16ClN5O4S. Formula Weight: 385.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml. SMILES: ClC1=CN=C(NC(N)=N)C2=C1C=CC(S(NC(C)(C)C(O)=O)(=O)=O)=C2. InChi Code: InChI=1S/C14H16ClN5O4S/c1-14(2,12(21)22)20-25(23,24)7-3-4-8-9(5-7)11(19-13(16)17)18-6-10(8)15/h3-6,20H,1-2H3,(H,21,22)(H4,16,17,18,19). InChi Key: XSDAXWRCPTYNOD-UHFFFAOYSA-N.