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UK-371804
Item number: TGM-T3442-100mg
Description: UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers. Target: PAI-1, Serine Protease. Smiles: CC(C)(NS(=O)(=O)c1ccc2c(Cl)cnc(NC(N)=N)c2c1)C(O)=O. References: Fish PV, et al. Selective...
| Keywords: | UK371804 |
| Application: | Urokinase-type plasminogen activator (uPA) inhibitor |
| CAS | 256477-09-5 |
| MW: | 385.83 D |
From 45.00€
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UK 371804
Item number: Cay27225-10
UK 371804 is an inhibitor of urokinase-type plasminogen activator (uPA, Ki = 10 nM). It is 4,000- and 2,700-fold selective for uPA over tissue plasminogen activator (tPA) and plasmin, respectively. UK 371804 inhibits exogenous uPA in human chronic wound fluid (IC50 = 0.89 µM). Topical administration of UK 371804...
| Keywords: | N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-alanine |
| Application: | Urokinase-type plasminogen activator (uPA) inhibitor |
| CAS | 256477-09-5 |
| MW: | 385.8 D |
From 133.00€
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