TUG-469

TUG-469 is an agonist of free fatty aid receptor 1 (FFAR1/GPR40). It induces calcium mobilization in a reporter assay using cells expressing human FFAR1/GPR40 (EC50 = 18. nM). TUG-469 (10 µM) induces insulin secretion in INS-1E insulinoma cells. It inhibits increases in blood glucose levels in a glucose tolerance test (GTT) in mice when administered at a dose of 5 mg/kg. InChI: InChI=1S/C23H23NO2/c1-17-5-2-3-8-22(17)20-7-4-6-19(15-20)16-24-21-12-9-18(10-13-21)11-14-23(25)26/h2-10,12-13,15,24H,11,14,16H2,1H3,(H,25,26), InChIKey: RUPXKSLKGSSZCP-UHFFFAOYSA-N, SMILES: O=C(CCC1=CC=C(NCC2=CC(C3=C(C)C=CC=C3)=CC=C2)C=C1)O