Trotabresib

Trotabresib is an inhibitor of bromodomain-containing protein 4 (BRD4, IC50 = =0.5 µM). It inhibits the proliferation of Raji Burkitt's lymphoma and HL-60 leukemia cells (IC50 = =0.5 µM for both).Formal Name: 4-[2-(cyclopropylmethoxy)-5-(methylsulfonyl)phenyl]-2-methyl-1(2H)-isoquinolinone. CAS Number: 1706738-98-8. Synonyms: BMS-986378, CC-90010. Molecular Formula: C21H21NO4S. Formula Weight: 383.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/ml, DMSO: 3 mg/ml. SMILES: O=C1C2=C(C(C3=C(OCC4CC4)C=CC(S(=O)(C)=O)=C3)=CN1C)C=CC=C2. InChi Code: InChI=1S/C21H21NO4S/c1-22-12-19(16-5-3-4-6-17(16)21(22)23)18-11-15(27(2,24)25)9-10-20(18)26-13-14-7-8-14/h3-6,9-12,14H,7-8,13H2,1-2H3. InChi Key: UWZAJPITKGWMFJ-UHFFFAOYSA-N.