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TP-0472993 is an inhibitor of the cytochrome P450 (CYP) isoforms CYP4A11 and CYP4F2 (IC50s = 140 and 40 nM, respectively). It is selective for CYP4A11 and CYP4F2 over a panel of eight additional CYPs at 10 µM. TP-0472993 inhibits 20-HETE (Cay-90030) production in rat renal microsomes (IC50 = 347 nM). In vivo, TP-0472993 (0.03-1 mg/kg) inhibits 20-HETE production in rats. It also reduces renal fibrosis and IL-1beta and TNF-alpha levels in a mouse model of folic acid-induced nephropathy and a mouse model of unilateral ureteral obstruction-induced neuropathy when administered at a dose of 3 mg/kg.Formal Name: 1-[4-[[[6-(1H-pyrazol-3-yl)-3-pyridinyl]oxy]methyl]-1-piperidinyl]-ethanone. CAS Number: 2126874-77-7. Molecular Formula: C16H20N4O2. Formula Weight: 300.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: O=C(C)N1CCC(CC1)COC2=CC=C(C3=NNC=C3)N=C2. InChi Code: InChI=1S/C16H20N4O2/c1-12(21)20-8-5-13(6-9-20)11-22-14-2-3-15(17-10-14)16-4-7-18-19-16/h2-4,7,10,13H,5-6,8-9,11H2,1H3,(H,18,19). InChi Key: GNQGSUOEYQIORN-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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